Loosing power and check engine light?

Hello , I have a 2000 S-10 extreme with a 4.3 vin#w and a couple of days ago me throttle got stuck down and had to shut off truck to make it stop. Then two days later I get a check engine light flashing and no power when trying to accelerate. Could this be a EGR valve problem. Any help would be great !! O and I already cleaned the throttle body and replaced the fuel sensor on side of throttle body.

Welcome to AF, start by getting the code scanned.

I did it gave me a P0300 wich is random missfire. I replaced the EGR valve and now the truck runs even worse. It is tapping and running very rough. Im really confused now. Sounds like somthing inside has come apart or somthing.